Multidimensional Mass Spectrometry-Based Shotgun Lipidomics

43 Multidimensional Mass Spectrometry-Based Shotgun Lipidomics 

MDMS-based shotgun lipidomics overcomes the majority of the limitations of other shotgun lipidomics approaches and possesses many obvious advantages as follows  

Limitations in MDMS-based shotgun lipidomics along with other shotgun lipidomics approaches include the following  

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Yang, K., Cheng, H., Gross, R. W., and Han, X. 2009. Automated lipid identification and quantification by multidimensional mass spectrometry-based shotgun lipidomics. AnaZ. Chem. 81 4356-68. 

Yang, K., Jenkins, C.M., Dilthey, B. and Gross, R.W. (2015) Multidimensional mass spectrometry-based shotgun lipidomics analysis of vinyl ether diglyceiides. Anal. Bioanal. Chem. 407, 5199-5210. 

The connection of SRM/MRM mode to other MS/MS modes is briefly mentioned earlier. In fact, the other MS/MS techniques (i.e., product-ion analysis, NLS, and PIS) are also interrelated. This interrelationship provides a foundation to multidimensional mass spectrometry-based shotgun lipidomics (MDMS-SL) and can be schematically illustrated with a simplified model system that comprises three molecular ions (/ i, m2, and m ) of a lipid class (Figure 2.8). 

MDMS-SL multidimensional mass spectrometry-based shotgun lipidomics... 

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