Zeolites multicomponent reactions

Cu(l)-modified zeolites, especially Cu(I)-USY, proved to be very efficient catalyst in multicomponent reaction. Such catalysts allowed for an efficient, solvent-free synthesis of propargylamines from aldehydes, amines and terminal alkynes with high yields. 

M. K. Patil, M. Keller, B. M. Reddy, P. Pale, J. Sommer, Copper-zeolites as green catalysts for multicomponent reactions an efficient and green synthesis of propargyl amines, Eur. J. Org. Chem., 2008, 26, 4440 445. 

Pale et al. developed the one-pot synthesis of 1,2,3-triazoles from alkylhalides, NaNj, and terminal alkynes mediated by a Cu(I)-modified zeolite (Scheme 4.15) (Beneteau et al., 2010). Also, Cn(I)-zeolites could smoothly promote the multicomponent synthesis of hydroxymethylated 1,2,3-trizoles from epoxides, NaN3, and terminal alkynes (Schane 4.16) (Boningari et al., 2010). However, a drawback of the method is that long reaction times are required. 

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