Multicatalytic Domino Processes

Multicatalytic domino processes are synthetic strategies in which two or more catalytic domino reactions are sequentially used in the synthesis of a compound Hbrary [8-10]. The product obtained from the first domino reaction is the substrate for subsequent cascades, which yield products with either a different scaffold or modified functional group formation. 

In 2011, Panteleev et al. reported a domino alkyne arylation and N-arylation process by combining rhodium and palladium catalysis [10], Based on a Rh-catalyzed alkyne arylation and subsequent Pd-catalyzed intramolecular N-arylation process, this multicatalytic cascade reaction efficiently incorporated amine-pendant aryl alkynes 25 and aryl boronic acid into functionalized dihydroquinoline derivatives (Scheme 9.7). 

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