Multi-target drugs

Csermely, P., etal., The efficiency of multi-target drugs the network approach might help drug design. Trends Pharmacol Sci, 2005, 26, 178-182. 

Fulfilling a Therapeutic Imperative in Cancer Treatment Control of Multi-target Drug Impact... 

As noted previously in this chapter, multi-target drugs may be more resilient against drug-resistant mutations [48], providing another motivation to exploit promiscuity. This assertion readily follows from the fact that cross-reactive drugs typically make interactions with evolutionarily conserved residues and fewer interactions with residues that need to mutate to confer drug resistance. 

Multi-target Drugs Strategies and Challenges for Medicinal Chemists... 

Wendt MD (2012) Targeting protein-protein interactions dual inhibitors of Bcl-2 and Bcl-xL. In Morphy JR, Harris CJ (eds) Designing multi-target drugs. RSC, Cambridge... 

Multi-target drugs can be discovered in various ways. Starting... 

A. Petrelli, and S. Giordano, From single- to multi-target drugs in cancer therapy when aspecificity becomes an advantage. Curr. Med. Chem., 15 (2008) 422-32. 

J., Bond, P.J., Whitmore, A.V., Zimmer, S., Young, M.P., Jenkins, J.L., Glick, M., Glen, R.C., and Bender, A. (2011) From in silico target prediction to multi-target drug design current databases, methods and applications. /. Proteomics, 74, 2554-2574. 

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