Multi-supported reagents

S. V. Ley, l.R. Baxendale, G. Brusotti, M. Caldarelli, A. Massi and M. Nesi, Solid-supported Reagents for Multi-step Organic Synthesis Preparation and Application, II Farmaco 57 321-330 2002. 

Ley, S.V., Schucht, O., Thomas, A.W., Murray, P.J. (1999) Synthesis of the Alkaloids ( )-Oxomaritidine and ( )-Epimaritidine Using an Orchestrated Multi-Step Sequence of Polymer Supported Reagents. Journal of the Chemical Society Perkin Transactions I, 1251-1252. 

Solid Supported Reagents in Multi-Step Flow Synthesis... 

Baxendale IR, Ley SV (2000) Polymer-supported reagents for multi-step organic synthesis application to the synthesis of sildenafil. Bioorg Med Chem Lett 10 1983-1986... 

Ley SV, Baxendale IR (2002b) New tools and concepts for modern organic synthesis. Nat Rev Drug Disc 1 573-586 Ley S V, Massi A (2000) J Comb Chem Polymer supported reagents in synthesis preparation of bicyclo[2.2.2]octane derivatives via tandem michael addition reactions and subsequent combinatorial decoration. 2 104—107 Ley SV, Schucht O, Thomas AW, Murray PJ (1999) Synthesis of the alkaloids ( )-oxomaritidine and ( )-epimaritidine using an orchestrated multi-step sequence of polymer supported reagents. J Chem Soc Perkin Trans 1 1251— 1252... 

Ley S V, Baxendale IR, Brusotti G, Caldarelli M, Massi A (2002b) Solid-supported reagents for multi-step organic synthesis preparation and application. Farmaco 57 321-330... 

Supported Reagents and Scavengers in Multi-step Organic Synthesis... 

This multi-step, one-pot process was taken further by integration of a third supported reagent for the sequential preparation of 3,5-diphenylpyrazole (Scheme 2.17). Following the previously established procedure, acetophenone was deprotonated and acylated to afford the 1,3-dicarbonyl species. This intermediate was easily separated from the spent polymers by filtration and passed without isolation into a suspension of the resin bound hydrazine salt (9), affording the desired pyrazole in 91% yield. In a subsequent publication, the authors reported that the depleted polymeric reagents from the first step of the conversion (i.e. (7) and (8)) were recovered and separated via a selective flotation procedure, enabhng them to... 

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