Multi-objective design

Filipe, R. M., S. Flauan, et al. (2007). Multi-Objective Design of Reactive Distillation. 17 ... 

Multi-Objective Design of Multipurpose Batch Facilities Using Economic Assessments... 

Chakraborty, A. and Linninger, A. A. (2002). Plant-wide waste management. 1. Synthesis and multi-objective design, Ind. Eng. Chem. Res., 41, pp. 4591-4604. 

Hakanen, J., Hakala, J. and Manninen, J. (2006). An integrated multi-objective design tool for process design, Appl. Therm. Eng., 26, 1393-1399. 

Multi-modal and Multi-objective Design Optimization... 

Recently fliere is interest in design optimization within a dynamic environment. Research is required to extend this to multi-objective design optimization. 

In the design of MOEMS components, various parameters have to be tuned. These parameters differ according to the functionality of the component. We will consider two different family of devices, programmable slits for Multi-Object Spectroscopy, including Micro-Mirror Arrays (MMA) and Micro-Shutters Arrays (MSA), and Micro-Deformable Mirrors (MDM) for Adaptive Optics systems. 

Stefanis etal.J Alexander etal./ Baitz etalJ and Sugiyama etal. ° and so forth likewise presented the coupling of LCA and economic evaluation with a multi-objective evaluation to aid process design and development. 

Molecular Library Design Using Multi-Objective Optimization Methods... 

Key words Multi-objective molecular library design, multi-objective evolutionary algorithm,... 

Instead, due to the multi-objective nature of drug discovery, other factors, such as absorption, distribution, metabolism, excretion, toxicity (ADMET), selectivity and cost, molecular screening libraries need to be carefully planned and a number of design objectives must be taken into account (8). In recent times, MLD efforts have been exploring the use of multi-objective optimization (MOOP) techniques capable of designing libraries based on a number of properties simultaneously (9). 

Multi-objective Molecular Library Design Applications... 

Recently, we proposed the Multi-objective Evolutionary Graph Algorithm (MEGA), an optimization algorithm designed for the evolution of chemical structures satisfying multiple constraints... 

Multi-objective Library Design Algorithm Description... 

Key words Combinatorial library design, computer algorithms, product properties, multi-objective optimization. 

In this paper, we extend the work of [10] by simultaneously considering minimization of the total utility consumption, maximization of operational flexibility to source-stream temperatures, and even minimum number of matches as multiple design objectives. The flexible HEN synthesis problem is thus formulated as the one of multi-objective mixed-integer linear programming (MO-MILP). This formulation also assumes that the feasible region in the space of uncertain input parameters is convex, so that the optimal solution can thus be explored on the basis of the vertices... 

Example 1. The 2-hot/2-cold streams example studied by [10], with problem data presented in Table 1, is illustrated. With these parameters, the multi-objective MILP formulation has 408 linear equality constraints, 760 linear inequality constraints, 12 binary variables, and 545 positive continuous variables. Notably, the restriction of MEUmax = 6 in Eq. (7) will be removed should the minimum number of matches be simultaneously taken into account as one of the design objectives. 

Multi-objective de novo design by Pareto-ranking and genetic operators on molecular graph-based chromosomes... 

We also discussed factors and models that need to be employed for the design against specific biological activities, and then introduced the importance of ADMET models. We have also reviewed ways to conduct comprehensive, balanced, multi-objective compound library design. These multi-objective methods should be applicable to gene family oriented library design as well, so... 

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