Multi-drug resistance associated protein

Huai-Yun H, Secrest DT, Mark KS, Carney D, Elmquist WF, Miller W. Expression of multi-drug resistance-associated protein (MRP) in brain microvessel endothelial cells. Biochem Biophys Res Commun 1998 243 816-820. 

Figure 2.1 Hepatocyte basolateral bile acid transporters. Protein-bound bile acids returning in portal blood are taken up by the hepatocyte via the sodium taurocholate co-transporting polypeptide (NTCP) and organic-anion-transporting polypeptide (OATP). In cholestasis bile acids may be returned to blood by the multi-drug-resistance-associated protein 3 (MRP3).

Figure 2.3 Absorption of bile acids by the cholangiocyte in the cholehepatic shunt. Bile acids are absorbed at the apical membrane of the cholangioc5de by the apical sodium-dependent bile-acid transporter (ASBT) that causes cholehepatic shunting of bile acids back to the hepatocyte. Absorbed bile adds are exported across the basolateral membrane by multi-drug-resistance-associated protein 3 (MRP3), a truncated form of ASBT or by the het-eromeric organic solute (OST) a and p forms. Bile adds cause choleresis that is rich in bicarbonate ions secreted by the chloride/bicarbonate ion exchanger.

MRP s multi-drug resistance associated proteins family... 

Diestra JE, Scheffer GL, Catala II, Maliepaard M, Schellens JH, Scheper RJ, Germa-Lluch JR, Izquierdo MA. Frequent expression of the multi-drug resistance-associated protein BCRP/MXR/ABCP/ABCG2 in human tumours detected by the BXP-21 monoclonal antibody in paraffin-embedded material. J Pathol 2002 198 213-219. 

Multi-drug resistance associated protein (MRP), member of the ATP binding Cassette transporter proteins, is particularly involved in glutathione-conjugates detoxification. In human bronchial ciliated ceUs MRP mRNA immunostaining was observed at the basolateral plasma membrane (Br6-CHOT et al. 1997). 

Li Y, Revalde JL, Reid G, Paxton JW (2011) Modulatory effects of curcumin on multi-drug resistance-associated protein 5 in pancreatic cancer cells. Cancer Chemother Pharmacol 68 603-610... 

Kaufmann, A. M. Toro-Ramos, A. J. Krise, J. P. Assessment of Golgi apparatus versus plasma membrane-localized multi-drug resistance-associated protein 1. Mol Pharm. 2008, 5, 787-794. 

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