Mullerian inhibitory substance

In the early mammalian female embryo the absence of the Mullerian inhibitory substance MIS permits continuing development of the Mullerian duct, while the absence of testosterone permits the Wolffian duct to degenerate. However, positive developmental signals are also required. Among these is the protein Wnt-4, a member of a large family of locally acting signal molecules (Section 4). Wnt-4 may be needed both for oocyte development and for further suppression of male development.261... 

---