Mucobromic acid

Addition of halogens proceeds stepwise, sometimes accompanied by oxidation. Iodine forms 2,3-diiodo-2-butene-l,4-diol (53). Depending on conditions, bromine gives 2,3-dibromo-2-butene-l,4-diol, 2,2,3,3-tetrabromobutane-l,4-diol, mucobromic acid, or... 

N 15.61% OB to C02 2.97% red-yel ndles mp, v sens, deton violently. V sol in w. Prepn is by reacting 20g of K nitrite with 20g of mucobromic acid in 70cc of ethanol at 30-35°. The salt deflagrates on contact with either coned... 

N-Methyb/>-toluenesulfonamide, 34, 97 /3-Methyl-S-valerolactone, 35, 87 Methyl vinyl ether, 34, 29 Methyl vinyl ketone, 37, 19 Michael condensation between 3-nitropro-pane and methyl acrylate, 32, 86 Monochlorourea, 30, 24, 25, 26 Monoethanolamine, 32, 19 Monoethyl malonate, 37, 34 Mucobromic acid, 32, 95... 

A simple method for the synthesis of maleic anhydride derivative 165 starting from 2,5-dimethyl-3-thienylboronic acid and commercially available inexpensive mucobromic acid 168 was reported (04IZV2238) (Scheme 52). The starting boronic acid was prepared in good yield from 2,5-dimethyl-3-iodothiophene. 

In a 2-1. three-necked round-bottomed flask, equipped with a thermometer, a dropping funnel, a mechanical stirrer and a gas vent (Note 1), are placed 258 g. (3.74 moles) of sodium nitrite and 250 ml. of water. The contents of the flask are heated and stirred to dissolve the solid. A solution of 258 g. (1 mole) of mucobromic acid 2 in 250 ml. of warm 95% ethanol is placed in... 

There is one literature report of a pyrimido[5,4-J]pyrimidyl analogue (186) of pteroic acid, which can be viewed as an 8-deaza-7-aza derivative [110]. In this approach (Scheme 3.35), hydroxyacetamidine was condensed with mucobromic acid in a modified Budesinsky procedure to produce 2-hydroxy-... 

MUCOBROMIC ACID (Acrylic acid, a,p-dibromo-p-f ormyl-)... 

The well-known conversion of certain furans into lactones has been further studied recently. 2-Furoic acid, which was labeled in the carboxyl group, gave radioactive C02 when oxidized by bromine water to mucobromic acid.341... 

Halogenated pyridazinones have been thus prepared from muco-chloric acid (35) 286,312-316 mucobromic acid, or the related chlorobromo acid. Instead of hydrazine semicarbazide can be used and the intermediate semicarbazone cyclized in hot acetic acid, loss of the carbamide group taking place simultaneously. Acid hydrazides likewise form hydrazones first, which cyclize with the aid of phosphorus oxychloride. Tosylhydrazones are reported to cyclize easily. ... 

Dichloropyridazin-3(2//)-one and its 2-substituted analogs can be easily synthesized via the condensation of mucochloric acid (1) with hydrazines [11-13]. Similarly, when mucobromic acid (2) is used as substrate 4,5-dibromopyridazin-3(2//)-ones are obtained. 2-Alkyl substituted 4,5-dihalopyridazin-3(2A)-ones are usually not prepared by a direct condensation but via a direct A-alkylation on commercially available... 

Chloro- (5) and 5-bromo-6-phenylpyridazin-3(2//)-one (6) are obtained by Friedel-Crafts alkylation of mucochloric (1) or mucobromic acid (2) with benzene followed by a reaction with hydrazine [11, 16, 17]. In the latter process one halogen atom is selectively eliminated. 

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