Mucins of the Gastrointestinal Tract

Nearly two decades ago pAiLLARo and Pribilla(1962, 1964) could demonstrate that sialic acid protects the intrinsic factor from proteolytic degradation. Moreover, release of Neu5Ac led to a loss of affinity to vitamin Bi2- 

Intrinsic factor should also be mentioned. This specific glycoprotein of the gastric juice binds vitamin Bj2 and is inactivated by desialylation. The molecule can be reactivated by resialylation or replacement of the negative charge by 

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