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Mucins, of T. cruzi

Purified GPIs, obtained by proteinase K digestion from the mucins of T. cruzi trypomastigotes (tGPIs), are potent inducers of nitric oxide, tumor necrosis factor-a and interleukin-12. The unsaturated fatty acid of the GPI alkylacyl-PI moiety is essential for bioactivity, but other features of the intact GPI are also necessary since the PI obtained by nitrous acid treatment was inactive.32 Correlation between GPI structure and proinflammatory activity in macrophages has been reviewed.52... [Pg.319]

The other two isomeric disaccharides, /i-D-Gaj/(l - 3)-d-G1cNAc and jS-D-Gal/-(1 6)-d-G1cNAc were also prepared,112 providing all of the disaccharides of Gal/ necessary for unequivocal identification of the component found in the mucins of T. cruzi. [Pg.329]

See other pages where Mucins, of T. cruzi is mentioned: [Pg.329]    [Pg.341]   
See also in sourсe #XX -- [ Pg.321 , Pg.322 , Pg.322 , Pg.323 , Pg.324 , Pg.325 , Pg.326 , Pg.327 , Pg.328 , Pg.329 , Pg.330 , Pg.331 , Pg.332 , Pg.333 , Pg.334 ]



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Mucines

Mucins

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