Mucins biosynthetic pathways

Here, we delineate the biosynthetic pathways of the most common types of protein glycosylation occurring in the secretory pathway mucin-type O-linked glycosylation, A-linked glycosylation, and the formation of glycosaminoglycans. In addition, we will briefly visit the biosynthesis of some less-common varieties of protein glycosylation. 

The characterization of the glycosyltransferases and biosynthetic pathways involved in the construction of the O-chains in the mucins... 

Figure 4.14 The Biosynthetic Pathways for the Saccharides of Porcine Submaxillary Mucin, as Derived from the Experiments of Beyer et al (1979). For details see the text.

Fig. 12. Biosynthetic pathway for ovine and porcine submaxillary mucins. Prot, protein GalNAc, N-acetyl-n-galactosamine SA, sialic acid Gal, D-galactose OSM, ovine submaxillary mucin PSM, porcine submaxillary mucin. See text for a discussion of this pathway.

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