Mucin type 0-glycans

The functions of the large gel-forming mucins include lubrication of the epithelial surfaces and protection from chemical and physical impact and microbial damage. Bacteria, viruses, and other microbes bind to mucin-type 0-glycans and are trapped by the viscous mucus layer. This may prevent their migration toward the epithelial cell surface and support their removal by ciliary action. Bacteria can also use the carbohydrate moieties of mucins as nutrients. 

Table 2 Structures of mucin-type 0-glycans and alterations in cancer...

Table 4 Mammalian glycosyltransferases involved in the synthesis of mucin-type 0-glycans...

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