MSP Receptor Regulation or Activation

Control of MSP actions on cells can be at the level of ligand or receptor (Table I). Generation of active MSP from pro-MSP has been reviewed in Section V. Receptor-based controls or activation are summarized in this section. 

Cleavage of plasma pro-MSP in extravascular sites Cell-bound pro-MSP convertase Fluid phase pro-MSP convertase 

Cleavage of locally produced pro-MSP testis embryonic development  

Upregulation of receptor expression as part of host defense response 

Increased receptor expression in abnormal cells (Section VII,B) 

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