MS drugs

Table 2.2 GPC spin column/ESI-MS drug screening high throughput aspects compounds assayed per day and protein consumed per compound. 

CPC Spin Column/ESI-MS Drug Screening Demonstration Papers... 

Hatorp V, Thomsen MS. Drug interaction studies with repaglinide repaglinide on digoxin or theophylline pharmacokinetics and cimetidine on repaglinide pharmacokinetics. J Clin Pharmacol 2000 40(2) 184-92. 

Nesvizhskii Al, Aebersold R. Analysis, statistical validation and dissemination of large-scale proteomics datasets generated by tandem MS. Drug Discov Today 2004 9(4) 173-181. 

LC/MS/MS to support the clinical development [104-108]. The conventional sample preparation procedures require labor-intensive sohd-phase extraction (SPE) sample pretreatment steps and extensive method development time for the LC/MS drug analysis. One of the popular alternatives to SPE is the resurgence of the on-line SPE or column switching techniques [109-111]. More recently, this strategy has been further developed to determine the drug candidates in human plasma by LC/MS/MS analysis [104,109,112]. 

FDA Consum (2005b) MS Drug withdrawn from market. May-June 39(3) 3. 

Wright MS. Drug-induced hemolytic anemias increasing complications to therapeutic interventions. Qin Lab Sci 1999 12(2) 115-18. 

R.B. van Breemen, D. Nikohc, J.L.Bolton, Metabolic screening using on-line ultrafiltration MS, Drug Metab. Disp., 26 (1998) 85. 

Lee DY. A novel dynamic flow system for sensitive radioactivity detection in LC/MS. Drug Metab Rev 2006 38 (Suppl 2) 33. 

Ohtsuki, S., Kawakami, H., Inoue, T., Nakamura, K., Tateno, C., Katsukura, Y, Obuchi, W, Uchida, Y, Kamiie, J., Horie, T., and Terasaki, T. (2014). Validation of uPA/SCID mouse with humanized liver as a human liver model protein quantification of transporters, cytochromes P450, and UDP-glucuronosyltransferases by LC-MS/MS. Drug Metab Dispos 42, 1039-1043. 

TLC Ethyl acetate/AcOH/CHCl, (98 1 1, v/v/v) 5 pL 10 pL ELDI-MS drugs Dyes and drugs [70]... 

Stojanovska, N., Tahtouh, M., Kelly, T., Beavis, A., and Fu, S. 2014. Qualitative analysis of seized cocaine samples using desorption electrospray ionization—Mass spectrometry (DESI-MS), Drug Test. Anal., 7(5) 393-400. doi 10.1002/dta.l684. 

Paul R, Tsanaclis L, Kingston R, Berry A, Guwy A. Simultaneous determination of GHB and EtG in hair using GCMS/MS. Drug Test Anal 2011 3 201—5. 

Bajrami B, Krishnan S, Rusling JF (2008) Microsome biocolloids for rapid drug metabolism and inhibition assessment by LC-MS. Drug Metab Lett 2 158-162... 

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