Moxonidine Beta blockers

CENTRALLY ACTING ANTI HYPERTENSIVES BETA-BLOCKERS Risk of withdrawal t BP (rebound t BP) with clonidine and possibly moxonidine Withdrawal of clonidine, and possibly moxonidine, is associated with t circulating catecholamines beta-blockers, especially non-cardioselective ones, will allow the catecholamines to exert an unopposed alpha action (vasoconstriction) Do not withdraw clonidine or moxonidine while a patient is taking beta-blockers. Withdraw beta-blockers several days before slowly withdrawing clonidine and moxonidine... 

Centrally acting antihypertensives (e.g. clonidine, moxonidine) ACE inhibitors + Clonidine Clonidine + Beta blockers Moxonidine + Miscellaneous... 

The presence of a beta blocker can exacerbate the rebound hypertension that follows the withdrawal of clonidine (see Clonidine + Beta blockers , p.882). Moxonidine is reported to have less affinity for central alpha-receptors than clonidine, and no such rebound hypertension has actually been seen when moxonidine is withdrawn. However, to be on the safe side the manufacturers advise that any beta blocker should be stopped first, followed by the moxonidine a few days later. ... 

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