Motor coordination, changes after

Both tests include a series of noninvasive observational (in cage) and interactive measurements to evaluate the neurofunctional integrity of the rat. Locomotor activity, behavioral changes, motor-affective (e.g., touch escape) and sensory (e.g., startle response) reflex responses, coordination and gait, CNS excitation (e.g., tremors), and autonomic features as pupil size and body temperature are evaluated (ICH, 2000). As a standard, these measurements are executed at several time points after the single-dose administration... 

---