Motilium - Domperidone

Motilium (Domperidone). Sanofi-Aventis. UK Summary ofproductcharacteristics, June 2004. 

Motilium contains domperidone, v/hich is a dopamine antagonist and acts on the chemoreceptor trigger zone. It is ineffective in motion sickness. Stugeron contains cinnarizine Avomine and Phenergan contain promethazine and Kwells contains hyoscine hydrobromide. Cinnarizine and promethazine are antihistamines, which are indicated in motion sickness and hyoscine hydrobromide is an antimuscarinic agent that is also used in motion sickness. 

In contrast to metoclopramide, domperidone predominantly antagonizes the dopamine Dj receptor without major involvement of other receptors. It is not available in the U.S. but has been used elsewhere (motilium, others) and has modest prokinetic activity in doses of 10-20 mg three times a day. Although it does not readily cross the blood-brain barrier to cause extrapyramidal side effects, domperidone exerts effects in the parts of the CNS that lack this barrier, such as those regulating emesis, temperature, and prolactin release. 

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