Motifs , immunoreceptors ITIM with

Chacko el al., 1996). Cell growth is arrested when the type II Fey receptor bl (FcyRIIbl) associates with the B cell receptor (BCR) by the interaction of their extracellular domains with immune complexes. Clustering FcyRIIbl with BCR induces the phosphorylation of the immunoreceptor tyrosine-based inhibitory motif (ITIM) within the FcyRIIb intracellular tail, which then allows SHIP to bind through its SH2 domain. Recruitment of SHIP to the cell membrane by FcyRIIb p-ITIM is believed to block extracellular Ca2+ uptake and cell growth via the inositol 5-phosphatase activity of SHIP. 

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