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2-Morpholinoethyl isocyanide amide synthesis

A rather different approach to peptide bond formation and amide synthesis in general is to treat a mixture of a carboxylic acid and an amine with an isocyanide 2-Morpholinoethyl Isocyanide is especially suitable), which effectively acts as a dehydrating agent (eq 3). The procedure can result in extensive racemization of both reactants and products which may be supressed by the addition of HOSu presumably an HOSu ester is the penultimate intermediate. The addition of HOSu also decreases racemization in polypeptide synthesis when Bates reagent [(Me2N)sP+]20 (BF4 )2 is used as the coupling agent. ... [Pg.226]

See other pages where 2-Morpholinoethyl isocyanide amide synthesis is mentioned: [Pg.581]   
See also in sourсe #XX -- [ Pg.6 , Pg.387 ]

See also in sourсe #XX -- [ Pg.387 ]

See also in sourсe #XX -- [ Pg.6 , Pg.387 ]

See also in sourсe #XX -- [ Pg.387 ]



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2-Morpholinoethyl isocyanide

Amide synthesis

Isocyanide synthesis

Isocyanides synthesis

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