Morpholine Linezolid

Metabolism - Linezolid is primarily metabolized by oxidation of the morpholine ring, which results in 2 inactive metabolites. Linezolid is not detectably metabolized by human cytochrome P-450 and it does not inhibit the activities of clinically significant human CYP isoforms. 

Further work in the area of the structural characterization of impurities and degradants of pharmaceuticals was also reported from the author s laboratories in 1999.107 First, the susceptibility of the morpholine substituent in the oxazolidinone antibiotic linezolid (41) was characterized using micro-NMR probe capabilities. Beginning from linezolid (41) photo-oxidation produced a transient pink color in... 

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