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Morphine selective alkylation

Grewe (1946) introduced a vital alkylation reaction via a very specific stereo-selective (trans) synthesis followed by acid-catalyzed intramolecular, aromatic substitution, which caused the B/C-c/s CfD-trans ring fusions found to be common in either morphine or its natural congeners. This study has paved the way for an altogether new morphinan analogues known as benzomorphans . A few classical examples of this group of compoimds are listed below, viz., levorphanol tartrate dextromethorphan hydrobromide butorphanol tartrate ... [Pg.317]

See other pages where Morphine selective alkylation is mentioned: [Pg.186]    [Pg.31]    [Pg.66]    [Pg.450]    [Pg.451]    [Pg.451]    [Pg.348]    [Pg.114]    [Pg.114]    [Pg.208]    [Pg.641]    [Pg.167]   
See also in sourсe #XX -- [ Pg.186 ]



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