Morphine dimethyl ether

Morphine dimethyl ether see codeine r Morphine-3 methoxymethyl-6 methyl ether — methochloride. nethyl ethi D. 200 EtOH r (Chap. I V). EtOH 399,398,... 

Catalytic hydrogenation [494-9] and electrolytic reduction [500] of morphine affords dihydromorphine [xi], which can also be obtained by the demethylation of dihydrocodeine the optical antipode can be prepared in the sinomenine series from (4-)-dihydrocodeine [502-3] (see Chap. XXVI], Dihydromorphine can be esterified [504], converted into ethers [371, 504], heteroethers [446-8], and di-ethers [505], Dihydromorphine dimethyl ether is identical with tetrahydrothebaine [505-7] it can be demethylated to dihydromorphine [506-7],... 

Pseudomorphine is not reduced to morphine by sodium amalgam, zinc, and hydrochloric acid or tin and hydrochloric acid [31]. Catalytic hydrogenation affords tetrahydropseudomorphine, which is also obtainable by the oxidation of dihydromorphine [56], Oxidation of morphine-6-methyl ether (heterocodeine) leads to pseudomorphine-(3 6 -dimethyl ether [56]. 

Demethylation of morphothebaine can be effected by heating with dilute hydrobromic acid at 170° C., the product being 6-hydroxyapo-morphine, which reduces silver nitrate very rapidly and is oxidized by atmospheric oxygen even more readily than apomorphine [16]. Morphothebaine and its dimethyl ether give dark green amorphous substances on oxidation with alcoholic iodine [5],... 

Outline several syntheses of 50. Use aq clic starting materials. Use catechol dimethyl ether as a starting material. (Morphine-8)... 

Codeine is the methyl ether of morphine and therefore is also prepared from morphine by methylating the phenolic hydroxyl group with diazomethane, dimethyl sulfate, or methyl iodide. 

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