Mood disorders, from SSRIs

Histrionic Personaiity Disorder (HPD). HPD has also received remarkably little study, but we can perhaps extrapolate from our experiences with BPD. HPD shares with BPD the target symptom of mood instability. Although medications seldom play a significant role in the treatment of HPD, SSRIs/SNRIs may provide some benefit in alleviating depression as well as in reducing affective lability. 

Serotonin, also known as 5-hydroxytryptamine (5-HT) is biosynthesized from tryptophan and is a neurotransmitter. Serotonin plays an important role in many behaviors including sleep, appetite, memory, and mood [52]. People with depressive disorders exhibit low levels of serotonin in the synapses. Protonated serotonin binds to a serotonin reuptake transporter protein, sometimes referred to as the serotonin transporter (SERT) and is then moved to an inward position on the neuron and subsequently released into the cjdoplasm. Selective serotonin reuptake inhibitors (SSRI) bind with high affinity to the serotonin binding site of the transporter. This leads to antidepressant effects by increasing extracellular serotonin levels which in turn enhances serotonin neurotransmission [53]. The SSRI class of antidepressants has fewer side effects than the monoamine oxidase inhibitors. 

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