Monooxygenases progesterone monooxygenase

Progesterone Monooxygenase Origin Cylindrocapron radicicola Fluka... 

Progesterone is the precursor of hydroxylated pregnane derivatives of the cortisone and aldosterone types (Fig. 129). In this transformation monooxygenases (C 2.6.4) and dehydrogenases (C 2.1) are involved. In animals the hydroxylated pregnenes undergo a rapid turnover (A 5.2). Transformation takes... 

The enzymatic oxidation of alkanes to produce alcohols is a simplified version of the reactions that produce the adrenocortical steroid hormones. In the biosynthesis of corticosterone from progesterone (Section 4-7), two such oxidations take place successively (a, b). It is thought that the monooxygenase enzymes act as complex oxygen-atom donors in these reactions. A suggested mechanism, as applied to cyclohexane, consists of the two steps shown below the biosynthesis. 

Synthesis of both progesterone and 17a-hydroxyprogesterone occurs in the endoplasmic reticulum from which these intermediates migrate to the mitochondrion, the location of the first reaction and the remainder of the pathways. The monooxygenases involved are all cytochrome P-450 enzymes but different electron-transport pathways transfer the electrons from NADPH to the... 

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