Monooxygenase heme containing

Some of the major enzyme groups that facilitate this transformation are heme-containing MOs of the cytochrome P450 type [111], alkane hydroxylases, xylene monooxygenases, styrene monooxygenases [105], and haloperoxidases [112],... 

Heme coenzymes (8) with redox functions exist in the respiratory chain (see p. 140), in photosynthesis (see p. 128), and in monooxygenases and peroxidases (see p. 24). Heme-containing proteins with redox functions are also referred to as cytochromes. In cytochromes, in contrast to hemoglobin and myoglobin, the iron changes its valence (usually between +2 and +3). There are several classes of heme (a, b, and c), which have different types of substituent - Ri to - R 3. Hemoglobin, myoglobin, and the heme enzymes contain heme b. Two types of heme a are found in cytochrome c oxidase (see p. 132), while heme c mainly occurs in cytochrome c, where it is covalently bound with cysteine residues of the protein part via thioester bonds. 

There is a great variety of iron-containing monooxygenases however, the heme-containing monooxygenases known so far are almost based on two classes of hemoproteins, the cytochromes P-450 and the closely related NO synthases [22],... 

CYTOCHROME P-450 A family of heme-containing isozymes involved in the metabolic processing of thousands of substances, notably the toxification and detoxification of xenobiotics. (See also MONOOXYGENASES)... 

Maurer, S. C., Schulze, H., Schmid, R. D., and Urlacher, V. 2003. Immobilisation of P450BM-3 and an NADP(+) cofactor recycling system Towards a technical application of heme-containing monooxygenases in fine chemical synthesis. Adv. Synth. Catalys.,345, 802-810. 

Cytochrome P450 (P450) enzymes are heme-containing monooxygenases found in Bacteria, Archaea and Eukarya that catalyze hydroxylations of aliphatic and aromatic compounds ( RH ) according to the overall reaction " ... 

If O2 is required for HAS activity, it would be reasonable to hypothesize that this heme-containing enzyme oxidizes heme O to heme A via successive P450-like monooxygenase reactions. If this is the case, then O2 should be incorporated into the oxidized products. When in vivo assays were performed using 100% 02, however, high-resolution mass spectrometry revealed that no... 

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