Monomethoxy polyethylene glycol activation

PEG-Intron PEG-Intron is used for the treatment of hepatitis C. The product consists of a covalent conjugate of the recombinant interferon- -2b with monomethoxy polyethylene glycol (PEG) supplied in vials with 74/rg, 118.4/rg, 177.6/rg, or 222/rg of the active ingredient and 1.11 mg sodium phosphate (dibasic,anhydrous),l.ll mg sodium phosphate (monobasic, dihydrate), 59.2 mg sucrose, and 0.074mg polysorbate 80. The powder is reconstituted with sterile water-for-injection. 

Veronese, F.M., Largajolli, R., Boccu, E., Benassi, C.A., and Schiavon, O. (1985). Surface modification of proteins activation of monomethoxy-polyethylene glycols by phe-nylchloroformates and modification of ribonuclease and superoxide dismutase. Alied Biochem. Biotechnol., 11, 141-152. 

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