Monolithic Cation-Exchange Media

As already outiined in Sections 3.4.1.6 and 3.12.2, monolithic separation media have made a significant impact on separation science because of the advantages they offer over packed columns. Polymeric monoliths consist of a single piece of highly porous material that does not contain interparticular voids typical of packed beds. Porous polymer monoliths are successfiilly used for the separation of biomolecules such as peptides and proteins for more than 10 years. The 

Like with ProPac WCX-10, the most important applications for the weak cation-exchange monolith are monoclonal antibody (mAb) separations. As outlined in great detail in Section 3.12.1, mAbs undergo several post-translational 

Column dimensions [length xi.d.] (mm) 50x4.6 50x1 50x4.6 50x1 

Base matrix material Polymethacrylate Polymethacrylate Polymethacrylate Polymethacrylate 

Functional group Carboxylic acid Carboxylic acid Sulfonic acid Sulfonic acid 

---