Monocrotaline-induced inflammation

In our laboratory, dogs, rats, mice, and hamsters have been exposed to CAPs. We also have the capability to study various animal models of disease, including rats with monocrotaline-induced inflammation and chronic bronchitis, mice with asthma, and dogs with acute coronary occlusion to model an angina attack. These studies have provided the preliminary basis for investigations of the mechanisms of response described in the foregoing. 

Rat models of monocrotaline-induced pulmonary vascular injury-inflammation (120,121) and chronic bronchitis, with their appropriate controls have been used in exposures of groups of 16 animals to CAPs and groups of 16 normal or diseased animals exposed to filtered air at the same temperature, pressure, and flow, as a control. The concentration factor of outdoor air particles was approximately 30-fold. Exposures to CAPs resulted in significant mortality with monocrotaline-induced inflammation and significant mortality in animals with chronic bronchitis. Table 2 lists concentration, mortality, and pathological findings in these studies (21). 

---