Monoclonal antibodies tumor targeting

Fig. 6.13. Schematic representation of a selective delivery obtained by antibody-directed en-zyme-prodrug therapy (ADEPT). An exogenous enzyme is coupled to a monoclonal antibody (mAb) targeted for tumor cells. In a second step, a prodrug is administered, which, as a selective substrate of the exogenous enzyme, will be selectively activated at the tumor site.

Monoclonal antibodies that target various specific antigens can be used to kill the tumor eells expressing speeifie antigens, especially in hematologic cancers. Rituximab, one of the eommonly used monoelonal antibodies, was suggested to mediate its aetion meehanism via antibody-dependent cellular cytotoxieity (ADCC),... 

Cancer can be treated in a variety of ways. The more traditional approaches include surgeries to remove tumors, radiation and chemotherapy to kill cancerous cells, and treatment with monoclonal antibodies that target specific tumors. 

---