Monoboronic acid chemosensors

Figure 6.6 a-Methylbenzylamine based fluorescent chiral boronic acid chemosen-sors (i ,i )-(-)-5 and (S,S)-(+)-5. The monoboronic acid chemosensor 6 is also presented. Anthracene was used as fluorophore. 

Interestingly, we observed a much larger fluorescence enhancement for (iS)-8 compared to the monoboronic acid chemosensor without an intramolecular boronate structure (Figure 6.14). An enhanced fluorescence... 

Fluorescent sensors based on monoboronic acid often exhibit selectivity for fructose. The development of glucose-selective chemosensors in the medical field is being pursued vigorously because of the need to measure blood glucose levels for the management of diabetes. 

Based on the fitting of the fluorescence responses, the binding constant for the combination of (/ )-sensor/D-tartaric acid is logATp 2.79 0.12 whereas for (i )-sensor/L-tartaric acid it has not been determined due to the negligible fluorescence change. Reference chiral chemosensors with a mono-chirogenic centre and monoboronic binding site were also prepared. Indeed,... 

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