Monoamine subfamily

Fig. 1). These monoamine transporters belong to the SLC6 gene family of Na -Cl"-coupled neurotransmitter transporters that is also referred to as the neurotransmitter sodium symporter (NSS) family (Chen et al., 2004). In addition to the monoamine transporters, the NSS family includes subfamilies of transporters for GABA, amino acids, creatine, and the osmolytes betaine and taurine (Chen et al., 2004). 

A different type of bioinformatics analyses focus on the analysis of specific sequence motifs and signatures, which may lead to different conclusions than the analysis of the overall sequence identity. For instance, two orphan receptors, GPR61 and GPR62, reported to have overall sequence identity of 30% to the human 5-HT6 receptor were thus classified as monoamine-like receptors. Strikingly, both of them show mutations of the D3 32 residue and should therefore belong to a different subfamily. 

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