Monoacylation polyols

In the course of our continuous efforts for site-selective acylation of polyols, catalyst 8 and its derivatives were found effective for direct site-selective monoacylation of digitoxin and lanatoside C, clinically used cardiac glycoside possessing multiple hydroxy groups (Fig. 11) [38, 39]. Lanatoside C in particular seems to be a challenging polyol natural product because it possesses eight free hydroxy groups. 

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