Moloka’iamines

Ilimaquinone (12) belongs to the same structural class and was isolated from Hippospon-gia metachromia.3i 36 It also showed modest antimalarial activity. Moloka iamine (13) is a... 

While there exist too many syntheses of bromotyrosine alkaloids to delineate here, two illustrative examples are those of moloka iamine (1865) and the mycothiol-S -conjugate amidase inhibitor 2068 (1866). 

Lacy C, Scheuer PJ (2000) New Moloka iamine Derivatives from an Undescribed Verongid Sponge. J Nat Prod 63 119... 

Missouri Botanical Garden collecting program. 26-27 MiMJxanttone, anti neoplastic uses of, 84-85 MoLoka iamine, 240-241 Monocols. collection preigram for, 35 Monoterpenes, from marine environments, 242 Muqubilin, 239-240... 

Lacy, C. and Scheuer, P.J. (2000) New moloka iamine derivative from an undescribed Verongid sponge. J. Nat. Prod., 63,119-121. 

Schoenfeld, R.C., Lumb, J.-P., Fantini, J and Ganem, B. (2000) Total synthesis of mololipids a new series of anti-FllV moloka iamine derivatives. Bioorg. Med. Chem. Lett., 10, 2679-2681. 

Different iV-methylation derivatives of moloka iamine, aplysamine 1 (54) 44), purealidin F (55), and G (56) 45), were obtained from an Australian sponge Aplysina sp. and the Okinawan sponge Pscanmaplysilla purea, respectively. 3,5-Dibromo-4-(3-dimethylaminopropoxy)phenethyl carbamic acid methyl ester (57) and its salt 58 were obtained as the first bromotyrosine derivatives containing a carbamate group from an Indian sample of Psammaplysilla purpurea 46), along with 59 47,48). 

Ganem et al. synthesized ceratinamine (60), moloka iamine (52), and molo-lipids (53), together with several analogues, for antifouling, anti-HIV and cytotoxicity studies (197-199). 

Several bromotyrosine alkaloids have been reported to possess antiviral activities (see Table XI). These include moloka iamine (52), mololipids (53), fistularin-3 (79) ll-ketofistularin-3 (82), and psammaplysin D (132). 

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