Molecule Synthesis and Degradation

Therefore, the waiting times always obey an exponential distribution, but the corresponding parameter (and so the distribution properties) depends on the system state. Intriguingly, the parameter of the exponential distribution results to be the addition of the propensities (probabilities of occurrence per unit time) of the two possible reactions molecule synthesis and degradation. Hence, we can define a state-dependent total propensity, ar, equal to the sum of the individual propensities, at, and this total propensity determines the waiting-time distribution, given the system current state. 

Fig. 4.3 Simulations of the production-decay process using the Gillespie algorithm and different values of the molecule synthesis and degradation rates...

This chapter generalizes the results in Chap. 4. Here we study molecule synthesis and degradation one more time, but take into consideration the case in which the synthesis process is catalyzed by an enzyme. To simplify the chemical master... 

Energy yield from fatty acid oxidation The energy yield from ihe P-oxidation pathway is high. For example, the oxidation of a molecule of palmitoyl CoA to C02 and H20 yields 131 AIRs (Figure 16.19). A comparison of the processes of synthesis and degradation of saturated fatty acids with an even number of car bon atoms is provided in Figure 16.20. 

Protein turnover results from the simultaneous synthesis and degradation of protein molecules. In healthy adults, the total amount of protein in the body remains constant because the rate of protein synthesis is just sufficient to replace the protein that is degraded. 

I n this and the next 14 chapters we consider the synthesis and degradation of small molecules in the living cell. These aspects of biochemistry are collectively referred to as intermediary metabolism because they focus on the small-molecule intermediates in metabolic pathways. In this chapter the principles governing the intermediary metabolism are discussed. 

Intermediary metabolism, the synthesis and degradation of small molecules, serves two functions It supplies the energy needed for the synthesis of macromolecules and other energy-requiring processes, and it furnishes these processes... 

The ability of HA to associate with itself, with cell surface receptors, with proteins, or with other GAGs64 speaks to the versatility of this remarkable molecule. The tight regulation required for HA deposition in association with these multiple and diverse processes depends on net levels of synthesis and degradation. 

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