Molecular sequence analysis

Doolittle, R. F. (1996). Computer Methods for Macro-molecular Sequence Analysis. Methods Enzymology, 266. 

Artificial neural networks are now widely used to solve various problems in genome informatics and molecular sequence analysis. Part III provides an in-depth discussion of special system designs and considerations for building neural networks for genome informatics applications (chapters 6-8), and broad reviews of state-of-the-art methods and their evaluations (chapters 9-11). 

The second use to which bioinformatics has been put in the drug discovery process is more fundamental. It is concerned with the use of techniques in molecular sequence analysis to generate relationships between sequenees that are themselves used to provide fundamental structures for databases of drug discovery information. Relationships between data elements are important because they help to place individual elements in a context that can be readily assimilated by the user of the system. In many situations, observers approach data from different points of view and bring to bear the richness of differing scientific experiences. Whether we care to admit it or not, "biologists" and "chemists" have dif-... 

For an easy introduction to bioinformatics, http //www. sequenceanalysis.com is a guide to molecular sequence analysis. The site tells how to use freely available software to compare an unknown sequence to all of the sequences in a... 

Protein Database, ICSD, the Inorganic Crystallographic Database and METALS, the Metals Database. These last four systems can be viewed as a source of building blocks for molecular modelling. Finally there is MMSA, Macro Molecular Sequence Analysis, data files and software tools for analysis of amino-acid and nucleotide sequences in proteins and nucleic acids. These systems (unlike those of the first group) are usually consulted by research scientists. 

Ffeijne, G. von, 1987. Sequence Analysis in Molecular Biology Treasure Trove or Trivial PursuiT Diego Academic Pre.ss. 

Nagao, R.T., Czamecka, E., Gurley, W.B., Schoffl, F. Key, J.L. (1985). Genes for low-molecular-weight heat shock proteins of soybeans Sequence analysis of a multigene family. Molecular and Cellular Biology, 5, 3417-28. 

Waterman, M. S. in Mathematical and Computational Problems in the Analysis of Molecular Sequences Bull. Math. Biol. 1984, 46) Pergamon Oxford, 1984 p. 473. Cf. other articles in this volume. 

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