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Molecular representations three-dimensional bond-line structures

Fig. 11.2. Schematic representation of the primary structure of secreted AChE B of N. brasiliensis in comparison with that of Torpedo californica, for which the three-dimensional structure has been resolved. The residues in the catalytic triad (Ser-His-Glu) are depicted with an asterisk, and the position of cysteine residues and the predicted intramolecular disulphide bonding pattern common to cholinesterases is indicated. An insertion of 17 amino acids relative to the Torpedo sequence, which would predict a novel loop at the molecular surface, is marked with a black box. The 14 aromatic residues lining the active-site gorge of the Torpedo enzyme are illustrated. Identical residues in the nematode enzyme are indicated in plain text, conservative substitutions are boxed, and non-conservative substitutions are circled. The amino acid sequence of AChE C is 90% identical to AChE B, and differs only in the features illustrated in that Thr-70 is substituted by Ser. Fig. 11.2. Schematic representation of the primary structure of secreted AChE B of N. brasiliensis in comparison with that of Torpedo californica, for which the three-dimensional structure has been resolved. The residues in the catalytic triad (Ser-His-Glu) are depicted with an asterisk, and the position of cysteine residues and the predicted intramolecular disulphide bonding pattern common to cholinesterases is indicated. An insertion of 17 amino acids relative to the Torpedo sequence, which would predict a novel loop at the molecular surface, is marked with a black box. The 14 aromatic residues lining the active-site gorge of the Torpedo enzyme are illustrated. Identical residues in the nematode enzyme are indicated in plain text, conservative substitutions are boxed, and non-conservative substitutions are circled. The amino acid sequence of AChE C is 90% identical to AChE B, and differs only in the features illustrated in that Thr-70 is substituted by Ser.
In Summary Determination of organic structures relies on the use of several experimental techniques, including elemental analysis and various forms of spectroscopy. Molecular models are useful aids for the visualization of the spatial arrangements of the atoms in structures. Condensed and bond-line notations are useful shorthand approaches to drawing two-dimensional representations of molecules, whereas hashed-wedged fine formulas provide a means of depicting the atoms and bonds in three dimensions. [Pg.39]


See other pages where Molecular representations three-dimensional bond-line structures is mentioned: [Pg.145]    [Pg.342]    [Pg.170]    [Pg.4]    [Pg.86]    [Pg.763]    [Pg.125]    [Pg.45]    [Pg.272]    [Pg.170]   
See also in sourсe #XX -- [ Pg.63 , Pg.64 ]




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Bond line

Bond-line structures

Bonded linings

Line representation

Line structure

Molecular bond representation

Molecular bonding

Molecular structure 3-dimensional

Molecular structure bonding

Molecular structure representation

Representation molecular

Structural representation

Structure representation

Three structures

Three-Dimensional Structure Representation

Three-dimensional representation

Three-dimensional structure

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