Molecular recognition entropy driven

Rekharsky, M.V., Inoue, Y., Tobey,S., Metzger, A., Anslyn, E. (2002) Ion-pairing molecular recognition in water Aggregation at low concentrations that is entropy-driven, JAm.Chem.Soc. 124, 14959-14967 ... 

Computer simulations of methane in water have provided a potential of average force for two CH molecules in water and the entropy of association [21 ]. A change of temperature from 275 to 317 K leads to a large increase in the clustering probability [22]. Such entropy-driven attraction may play an important role in molecular recognition of flexible molecules in aqueous solution. 

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