Molecular modeling classes

Write structural formulas or build molecular models and give the functional class and substitutive names of all the isomeric alcohols that have the molecular formula C4H10O... 

Wnte structural formulas or build molecular models for all the constitutionally isomenc alcohols of molecular formula C5H12O Assign a substitutive and a functional class name to each one and specify whether it is a pnmary secondary or tertiary alcohol... 

Another group of macrocyclic ligands that have been extensively studied are the cycHc polyethers, such as dibenzo-[18]-crown-6 (5), in which the donor atoms are ether oxygen functions separated by two or three carbon atoms. The name crown ethers has been proposed (2) for this class of compounds because of the resemblance of their molecular models to a crown. Sandwich stmctures are also known in which the metal atom is coordinated with the oxygen atoms of two crown molecules. 

A large number and diverse classes of compounds have been reported to possess tyrosinase inhibitory activities to various extents from the millimo-lar to nanomolar concentration ranges. From our laboratory we have also reported a large variety of tyrosinase inhibitors and for some of them we have performed molecular modeling as well. Among them there are several alkaloids, and nitrogen-containing molecules are also present. 

Abstract Protoberberine alkaloids and related compounds represent an important class of molecules and have attracted recent attention for their various pharmacological activities. This chapter deals with the physicochemical properties of several isoquinoline alkaloids (berberine, palmatine and coralyne) and many of their derivatives under various environmental conditions. The interaction of these compounds with polymorphic DNA structures (B-form, Z-form, H -form, protonated form, triple helical form and quadruplex form) and polymorphic RNA structures (A-form, protonated form, triple helical form and quadruplex form) reported by several research groups, employing various analytical techniques such as spectrophotometry, spectrofluorimetry, circular dichro-ism, NMR spectroscopy, viscometry as well as molecular modelling and thermodynamic analysis to elucidate their mode and mechanism of action for structure-activity relationships, are also presented. 

The resultant data have led to the proposal of numerous molecular models of amyloid fibril structure (Makin and Serpell, 2005). These models can be separated into three general classes (Fig. 2) (1) the Refolding models,... 

N. Delaunay, V. Pichon and M.C. Hennion, Experimental comparison of three monoclonal antibodies for the class-selective immunoextraction of triazines. Correlation with molecular modeling and principal component analysis studies. J. Chromatogr.A 999 (2003) 3-15. 

In contrast, the existence of peptide-carbohydrate mimicry is more surprising in that it is difficult to picture how these two different classes of compounds could mimic each other. The origin of this effect at the molecular level has been the subject of recent investigations by NMR spectroscopy, X-ray crystallography, and molecular modeling. In combination with functional data, these studies provide insight into the nature of this phenomenon. 

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