Molecular Libraries Probe Production Centers Network

MLPCN Molecular Libraries Probe Production Centers Network... 

NIH MOLECULAR LIBRARIES PROBE PRODUCTION CENTERS NETWORK... 

Purpose The Molecular Libraries Roadmap offers public sector biomedical researchers access to the large-scale screening resources through the Molecular Libraries Probe Production Centers Network (MLPCN). The MLPCN has established a collection of 250,000 chemically diverse small... 

HTS is no longer limited to industrial settings and is starting to play an increasingly important role in academic research.112,113 With the new National Institutes of Health (NIH) initiatives in the USA to support a number of screening Molecular Libraries Probe Production Center Network (MLPCN) centres (http //ncgc.nih.gov/index.html) for academic research, it can be expected that the mutual impact of HTS and basic biology will increase. 

It is only in the past 5 years or so that chemical probe development has really taken off. This has largely been driven by the NIH roadmap initiative which engaged a network (Molecnlar Libraries Probe Production Centers Network http //mli.nih.gov/mli/ mlpcn/mlpcn/) of academic-based centers that provided state-of-the-art high-throughput screening (HTS) capabilities of a large diverse small-molecule library (the Molecular Libraries Small Molecule Repository (MLSMR) >350,000 compounds) as well as much expertise in the activities of assay development and downstream hit to probe (http //mli.nih.gov/mli/). Prior to this initiative, HTS was almost exclusively conducted within pharmacentical... 

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