Molecular genetics schizophrenia

Buckland PR and McGuffin P (2000). Molecular genetics of schizophrenia. In MA Reveley and JFW Deakin (eds), The Psychopharmacology of Schizophrenia (pp. 71-88). Edward Arnold, London. 

Owen, M.J. (2000) Molecular genetic studies of schizophrenia. Brain Res Brain Res Rev 31 179-186. 

Lawrie SM, Hall J, McIntosh AM, Cunningham-Owens DG, Johnstone EC. 2008. Neuroimaging and molecular genetics of schizophrenia Pathophysiological advances and therapeutic potential. Brit J Pharmacol 153 S120-S124. 

Owen MJ, Williams NM, O Donovan MC. 2004. The molecular genetics of schizophrenia New findings promise new insights. Mol Psychiatry 9 14-27. 

Faraone SV, Taylor L, Tsuang MT. 2002. The molecular genetics of schizophrenia An emerging consensus. Expert Rev Mol Med 2002 1-13. 

The neurochemical and molecular genetic study of psychoses including schizophrenia is beset by problems of clinical definition. 

Maier W, Schwab S. Molecular genetics of schizophrenia. Curr Opin Psychiatry 1998 11 19-25. 

Regulation of homocysteine metabolism appears to be especially important in the central nervous system, presumably because of the critical role of methyl transfer reactions in the production of neurotransmitters and other methylated products. It has been known for decades that mental retardation is a feature of the genetic diseases, such as CBS deficiency, that cause severe hyperhomocysteinemia and ho-mocystinuria. Impaired cognitive function is also seen in pernicious anemia, which causes hyperhomocysteinemia due to deficiency of cobalamin (see Chapter 28). Hyperhomocysteinemia also may be linked to depression, schizophrenia, multiple sclerosis, and Alzheimer s disease. The molecular mechanisms underlying these clinical associations have not yet been delineated. 

---