Molecular chemosensors

Three new fluorescent indolizine modified /3-cyclodextrins have been investigated as molecular chemosensors for the detection of volatile organic compdounds <2007MI312>. 

Fig. 32 Effect of analyte coordination in (a) a traditional molecular chemosensor system, (b) receptors wired in series in a conjugated polymer, (c) chemosensors grafted onto the surface of a nanoparticle, and (d) a fluorescent dendrimer. The curved arrows indicate the active...

Fig. 2 Comparison between the signals arising from a molecular chemosensor and a nanoparticle-based one...

Ballesteros-Garrido R, Abarca B, Ballesteros R, de Arellano CR, Leroux FR, Colobert F, Garcia-Espana E (2009) [l,2,3]Triazolo[l,5-a]pyridine derivatives as molecular chemosensors fin Zinc(II), nitrite and cyanide anions. New J Chem 33 2102-2106... 

Fleterocycles as chemosensors in molecular wire approach to sensory signal amplification 98ACR201. 

Oguz U, Akkaya EU (1997) One-pot synthesis of a red-fluorescent chemosensor from an azacrown, phloroglucinol and squaric acid a simple in-solution construction of a functional molecular device. Tetrahedron Lett 38 4509 1512... 

Zhou Q, Swager TM (1995) Fluorescent chemosensors based on energy migration in conjugated polymers the molecular wire approach to increased sensitivity. J Am Chem Soc 117 12593-12602... 

An overview of the synthesis, structure, photophysical properties, and applications of squaraine rotaxanes as fluorescent imaging probes and chemosensors is provided in a recent review [67]. Although a variety of squaraine dyes form rotaxanes with the molecular cage 25 or with a tetralactam macrocyclic system introduced by Leigh and co-workers [16, 17], there is no evidence in the literature that conventional cyanine dyes can be embedded in these macrocycles. 

Fan L-J, Zhanga Y, Murphy CB, Angell SE, Parker MFL, Flynn BR, Jones WE Jr (2009) Fluorescent conjugated polymer molecular wire chemosensors for transition metal ion recognition and signaling. Coord Chem Rev 253 401 122... 

Despite the remarkable progress in the field of molecular recognition, it is still extremely difficult to predict a priori the structure of a selective, high-affinity ligand for a metal ion such as Hg ". The approach we intend to pursue is to take advantage of combinatorial chemistry methods—a collection of technical advances that allow one to seriously consider undertaking the synthesis of hundreds or even thousands of compounds simultaneously —to carry out the parallel synthesis of a set of fOO potentially selective high-affinity fluorescent chemosensors for mercury. 

M. Lahav, A. B. Kharitonov, O. Katz, T. Kunitakc, and I. Willner, Tailored Chemosensors for Chloroaromatic Acids Using Molecular Imprinted Tt02 Thin Films on Ion-Sensitive Field-Effect Transistor, AnaL Chem. 2001, 73, 720. 

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