Molecular Biology of OST

Of the thermostable transferases, the nucleotidyl transferases have received the most attention in recent years. This is due to the interest in DNA polymerases which mediate the polymerisation chain reaction [156], i.e. the amphfication of sequences of DNA. This reaction forms the basis of a number of commercial applications in the fields of medicine and forensic science, as well as in research in molecular biology (see Oste [157]). 

In this review we will try to summarize the current knowledge of biochemistry and molecular biology of the OST from lower and higher eukaryotes. Sequence search in databases indicate also homologous proteins in archaea that may be involved in the A-glycosylation of these organisms. The reader is also referred to previous reviews dealing with this topic [28 31]. 

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