Molds proteases

It has also been shown by Kunitz that trypsinogen is activated by first-order reactions induced by other enzymes such as enterokinase and mold proteases. As in autoactivation, activation by purified enterokinase runs parallel with the appearance of an NH2-terminal isoleucine (57). But the hexaf ptide has not been isolated in this experiment and enterokinase acts in a pH range where autoactivation occurs at a quick rate. More work is clearly needed before the identity of both proces.ses is firmly established. 

Ovalbumin Pepsin, trypsin, chymotrypsin, mold protease Glycopeptides Johansen et al. (1961)... 

Penicillium caseicolum produces an extracellular aspartyl proteinase and a metalloproteinase with properties very similar to those of the extracellular enzymes produced by P roqueforti (Trieu-Cout and Gripon 1981 Trieu-Cout et al. 1982). Breakdown of casein in mold-ripened cheese results from the synergistic action of rennet and the proteases of lactic streptococci and penicillia (Desmazeaud and Gripon 1977). Peptidases of both lactic acid bacteria and penicillia contribute to formation of free amino acid and nonprotein nitrogen (Gripon et al. 1977). 

Other Bacterial, Mold, and Yeast Proteases Hiroshi Matsubara and Joseph Feder... 

After the first successful attempts in 1928 to identify the active biochemicals found in antibacterial molds, followed the rediscovery of penicillin by Fleming, identification of its chemical structure by Hodgkin, and subsequent synthesis by Chain, Heatley, and Florey, which led to the commercial production of penicillin in the mid 1940s [1], Since then, other families of (3-lactam antibiotics have been developed [2, 3], and their massive use worldwide continues to be a forefront line of action against infectious pathogens [4-6]. In recent years, (3-lactams have found other biomedical applications, such as inhibitors of serine protease ([7, 8] for a review, see [9]) and inhibitors of acyl-CoA cholesterol acyltransferasa (ACAT) [10]. Encouraged by their bioactivity, the synthesis and chemistry of (3-lactam antibiotics have been the focus of active research, and chemical modification of some basic structures available from biosynthesis (semisynthetic approaches) as well as the discovery of fully chemical routes to de novo synthesis of (3-lactam... 

Inhalatory and Contact Allergens of Mold Origin of the Subtilisin-Like Serine Proteases Family... 

Acid proteases play an important role in two major areas of food processing—cheese making and the production of fermented foods by molds from soy beans, rice, and other cereals. 

Acid proteases probably also play a role in the breakdown of cheese proteins by species of Fenicillia used to produce blue cheeses (Roquefort, Stilton, Danish Blue) and soft cheeses (Camembert, Brie, etc.). The curds are inoculated with spore preparations of the appropriate mold. The growing mold then converts the curd into the desired cheese through the action of different enzymes. 

Matsubara, H., and J. Feder (1971), Other Bacterial, Mold, and Yeast Proteases, in P. D. Boyer, Ed., The Enzymes, Vol. 3, Hydrolysis Peptide Bonds, 3rd ed., Academic-Press, New York, pp. 721-795. 

Neutral protease Mold, bacteria Bakery protein hydrolyzates... 

There is very little information about many of the bacterial or fungal proteases, which are produced in large quantities by many organisms. Recently several have been crystallized. Crude preparations of mold and of bacterial media have been used commercially for their protease activity. A crystalline protease from BaciUus subtUis, subtilisin, has been... 

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