Modulating factors organic acids

Extrinsic stabilization from low-molecular-mass "thermoprotectants." The intrinsic stability of a protein reflects selection for an amino acid sequence that confers on the protein the appropriate balance between rigidity and flexibility that is required for physiological function under the thermal conditions facing the organism. This being said, the stability of the protein in vivo may be modulated by extrinsic factors, including pH, which varies with temperature, and low-molecular-mass organic osmolytes, whose concentrations may be tern-... 

The last three statements (i.e., e., f., and g.) are all consistent with the observation in Section 3.5.4.3 d. that other factors (e.g., the physiochemical and biotic environments and other organic and inorganic compounds) modulate/regulate the effects of phenolic acids. Additional support for the role of physicochemical and biotic environmental factors in determining the effects of phenolic acids was also provided by our model system studies with phenolic acids (see Section 2.5). 

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