Modification on C-3 Position of BA

As mentioned previously, the C-3 hydroxyl group can be readily acylated with a wide variety of anhydrides and acid chlorides.30 Modification on this site of BA 1 and dihydro-BA 3 in our laboratory afforded a group of C-3 ester derivatives 7-22 (Table 13.1). 

From Natural Product to Clinical Trials Bevirimat, an Anti-AIDS Drug 

Comp d CC50 (liM) ECS0 (pM) TI Comp d CCso (pM) ECso (pM) TI 

CC50 = 50% cytotoxic concentration, the drug concentration that inhibits cell growth by 50% in vitro. 

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