Surface modification of collagenous

Modification of Collagenous Surfaces by Grafting Polymeric Side Chains to Collagen and Soft and Hard Tissues... 

From the studies summarized above, it is clear that the breakdown of the dentin matrix plays an important role in the pathology of dentin- and root surface caries. In addition, the demineralized dentin can be modified by a number of reactions, with consequences for its degradability. The studies described in this thesis were designed to address the role of degradation and modification of the dentin collagen. 

The appearance of the products of the reaction of collagen and various monomers often varied considerably from the original collagen powder 45, 48). With some monomers, the graft copolymer consisted of powders while with others mats or films were formed. The modification of surface properties could often be detected by visual inspection. 

The cell-binding properties of chitosan have led to numerous studies where chitosan is used as a surface coating. Chitosan was employed as a surface modification of poly(e-caprolactone) scaffolds and in vitro studies with fibroblasts showed significantly improved cell attachment and proliferation when chitosan was present. In another study, polyurethane scaffolds were prepared and surface-modified with chitosan for the same reason. This study showed that on the modified scaffold a monolayer of endothelial intima was formed. The incorporation of collagen with chitosan as a chi-tosan-collagen scaffold enhanced the resultant scaffold s ability to support cell attachment and is a strategy similar to the incorporation of peptide sequences. ... 

Cheng, Z. and Teoh, S.-H. 2004. Surface modification of ultra thin poly ( -caprolactone) films using acrylic acid and collagen. 25 1991-2001. 

---