Motility model

Studies on muscle contraction carried out between 1930 and 1960 heralded the modem era of research on cytoskeletal stmctures. Actin and myosin were identified as the major contractile proteins of muscle, and detailed electron microscopic studies on sarcomeres by H.E. Huxley and associates in the 1950s produced the concept of the sliding filament model, which remains the keystone to an understanding of the molecular mechanisms responsible for cytoskeletal motility. 

Huang, B. (1986). Chlamydomonas reinhardtii. A model system for genetic analysis of flagellar structure and motility. Inti. Rev. Cytol. 99, 181-215. 

Theriot, J.A., Mitchison, T.J. (1992). The nucleation-release model of actin filament dynamics in cell motility. Trends Cell Biol. 2,219-222. 

Brady, S. T., Lasek, R. J. and Allen, R. D. Video microscopy of fast axonal transport in isolated axoplasm A new model for study of molecular mechanisms. Cell Motil. 5 81-101, 1985. 

Dufort PA and Lumsden CJ [1996] How profilin/barbed-end synergy controls actin polymerization a kinetic model of the ATP hydrolysis circuit. Cell Motil... 

Chiba, T., Bharucha, A.E., Thomforde, G.M., Kost, L.J., and Phillips, S.F., Model of rapid gastrointestinal transit in dogs effects of muscarinic antagonists and a nitric oxide synthase inhibitor, Neurogastroenterol. Motil., 14, 535, 2002. 

Locomotor activity is measured in motility boxes equipped with photocells. Both horizontal and vertical movements can be registered in the modern boxes. Pretreatment with reserpine (18 h) renders the animals virtually without movement, an akinetic Parkinson-like state. It also makes postsynaptic D2 receptors supersensitive, since the receptors have been exposed to low concentrations of DA for a long period of time. The model is thus useful to reveal D2 agonists with a low degree of intrinsic efficacy and, the intrinsic efficacy of a series of partial agonists can be rated by this model. 

BASIC FEATURES OF THE ACTIN-BASED MOTOR COMPLEX. These experiments support the following model for Listeria actin-based motility. The Listeria surface protein ActA uses its oligoproline sequences (FEFPPPPTDE) to bind the host cell protein VASP. VASP in turn deploys its own larger set of GPPPPP sequences to bind profilin. 

ACTIN-BASED BACTERIAL MOTILITY ACTIN FILAMENT GROWTH (Polymerization Zone Model)... 

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