Model proving, chemist activity

One of the most attractive features of the CoMFA and CoMFA-like methods is that, because of the nature of molecular field descriptors, these approaches yield models that are relatively easy to interpret in chemical terms. Famous CoMFA contour plots, which are obtained as a result of any successful CoMFA study, tell chemists in rather plain terms how the change in the compounds size or charge distribution as a result of chemical modification correlate with the binding constant or activity. These observations may immediately suggest to a chemist possible ways to modify molecules to increase their potencies. However as demonstrated in the next section, these predictions should be taken with caution only after sufficient work has been done to prove the statistical significance and predictive ability of the models. 

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