Model for end-stage liver disease

INR, International Normalized Ratio MELD, Model for End-Stage Liver Disease. 

Model for end-stage liver disease (MELD) and paediatric end-stage liver disease (PELD)... 

Brown R, Kumar K, Russo M, Kinldiabwala M, Rudow D, Harren P, et al. Model for end-stage liver disease and Child-Turcotte-Pugh score as predictors of pretransplantation disease severity, posttransplantation outcome, and resource utilization in United Network for Organ Sharmg status 2A patients. Liver Transpl 2002 8 278-84. 

Acid-base balance Of 16 patients with hepatic cirrhosis and chronic hepatitis B infection, five developed lactic acidosis after 4—240 days of treatment with entecavir all five had highly impaired liver function [13 ]. One patient died, but in the other four the lactic acidosis resolved after withdrawal of entecavir. The serum lactate concentrations were not increased in the other 11 patients, who all had less severe liver impairment. Child-Pugh scores did not correlate with the development of lactic acidosis, but MELD (Model for End-Stage Liver Disease) scores did, as did serum bilirubin, creatinine, and international normalized ratio (INR). The authors suggested that entecavir should be used cautiously in patients with severely impaired liver function. 

MELD (model for end-stage liver disease) A mathematical model used to predict the 3-month mortality of a patient with chronic fiver disease. 

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